since i first wrote this post a few years ago, there have been many new favorable oral minoxidil and 2022世界杯决赛日期 related studies. the news media has also widely covered this subject since mid-2022. i will keep republishing this post every time there are a few new updates to discuss on top.
please consult your doctor or dermatologist before taking oral or sublingual minoxidil. one of the studies i discuss in this post warns on the dangers of compounded low-dose oral minoxidil (ldom) often being of a much higher dosage due to compounding error. the generic versions at your local pharmacy are likely safe.however, taking this drug is no joke and it must be used under medical supervision.
oral minoxidil and 2022世界杯决赛日期 updates
update: january 13, 2023— the respected dr. bisanga of thebhr clinicin belgium just sent me some amazing 8-month before and after photos of a patient of his who is taking 5mg oral minoxidil per day.
update: november 21, 2022— the below is an interesting quote from dr. rodney sinclairin a new articleon oral minoxidil for 2022世界杯决赛日期 . so “quentin” who in 2021 pushed me into discussingamino acids(especially cysteine) for 2022世界杯决赛日期 was perhaps justified.
“minoxidil prolongs anagen duration (increasing hair length), increases fiber diameter, reduces breakage and reverses hair miniaturization. it does this by increasing the uptake of the amino acidcysteineinto the hair bulb outer root sheath. transport of cysteine into hair cortex keratinocytes in the emerging anagen fiber is the final step in hair keratinization and the rate-limiting step in 2022世界杯决赛日期 .”
update: november 9, 2022— a highly encouraginganecdotal reportfrom a long-time 74-year old reader (and hospital pharmacy consultant) who i fully trust. he has never seen a drug as effective as low-dose oral minoxidil for 2022世界杯决赛日期 , and he has tried them all. his past hair transplant surgeon who i know well also verified his legitimacy.
update: october 13, 2022— in a recent article fromthe prestigious cleveland clinic, dr. wilma bergfeld is full of praise for oral minoxidil. key quote:
“it has really been the best drug we ever had for 2022世界杯决赛日期 .”
update: october 7, 2022— how australia iswinning the 卡塔尔世界杯赛程表 battle. dr. rodney sinclair is quoted as follows regarding low-dose oral minoxidil:
“we’ve now treated 20,000 people with it. it’s been a game changer 卡塔尔世界杯赛程表 treatment. minoxidil [as a pill] has pretty much100 per cent success at stopping progression. regrowth will be about 20 per cent of what they’ve lost.”
really amazing if true. dr. sinclair’s patients are prescribed doses ranging from 1-5 milligrams of minoxidil. this compares to 10-40 milligrams when used as a blood pressure treatment.
update: august 25, 2022— yet another great video, with several impressive before and after photos. courtesy of the well known hair transplant surgeon dr. nicole rogers.
update: august 18, 2022— the new york times just published an article on oral minoxidil for 卡塔尔世界杯赛程表 . it describes the drug as anold medicine that grows new hairfor pennies a day. it is becoming increasingly popular for off-label use in treating 卡塔尔世界杯赛程表 . dr. brett king makes an interesting point about their likely never being expensive clinical trials for such a low-cost product.
a new study finds that serious adverse side effects with low-dose oral minoxidil for 卡塔尔世界杯赛程表were due to compounding errors. after pharmacological lab analysis of formulated capsules, it was found that all the patients with serious side effects were receiving much higher doses than prescribed. this was due tocompounding mistakes. while the prescribed dose of oral minoxidil ranged between 0.5 and 1 mg, these patients were getting between 50 and 1000 mg per capsule. please be careful if you ever go this route for your 卡塔尔世界杯赛程表 treatment.
note that per the above article, doses of between 1.25 and 5 mg can be obtained by halving or quartering the marketed drug (loniten®, pfizer). the above issue is only with compounded ldom of 1mg or lower. according to dr. robert haber (us):
“i never recommend compounded minoxidil. rather, i prescribe the 2.5mg tablet and have the patient cut them in half or quarters, depending on the dose.”
update: march 4, 2022— a new study (with dr. jerry cooley as a co-author) concludes that oral minoxidil can bean effective treatmentfor androgenetic alopecia and telogen effluvium.
update: january 5, 2022— comingfull circlein the use of low-dose oral minoxidil (ldom) in the treatment of alopecia.
sublingual versus oral minoxidil
recently, “nik” on our discord group mentioned how sublingual minoxidil (3 mg/day) was superior to oral minoxidil in growing hair amongst his friends. make sure to read my past post on minoxidilas a sublingual tablet.
he then linked tothis 2020 report on 64 patientswhere the dose was only 0.45 mg/day. the author is dr. rodney sinclair of australia, who i cover in detail at the bottom of this post. iposted about this on twitter, and dr. corralo and dr. bhoyrul responded with very interesting comments:
upon further research, i also found thisnewer august 2021 reportfrom dr. sinclair. it entails a phase 1b clinical trial, which is very encouraging news. detailed summary from october 2021can be read here. the interest in oral minoxidil for 2022世界杯决赛日期 has really taken of during the past few years. online anecdotes indicate superiority over topical minoxidil, but i am not yet 100 percent certain.
“almost 67% of patients who received the 4.05 mg dose experienced improvements in frontal and vertex hair density. in the 0.45 mg dose group, phototrichograms showed a mean increase in terminal hair count/cm2 of 4 for the frontal and 9 for the vertex scalp. treatment with the 1.35 mg dose resulted in a mean increased terminal hair count/cm2 of 10 and 26.the 4.05 mg dose led to a mean increase terminal hair count/cm2 of 38 for the frontal and 88 for the vertex scalp.“
according todr. mirmirani’s succinct summaryat the bottom of that page:
“the authors suggest that sublingual minoxidil (sm) may have better bioavailability and fewer hemodynamic effects by avoiding first-pass liver metabolism. will sm be a game changer? although the data in this study are positive, it will take more to convince me that it is significantly better than oral minoxidil (om). very few of my patients on low-dose om for 卡塔尔世界杯赛程表 discontinue the medication due to side-effects. the other consideration is cost. om it is an inexpensive, generic drug, that is covered by medical benefits.”
update:aninteresting thread on twitterregarding sublingual minoxidil.
other newer studies
update: october 2021— new study finds that low-dose oral minoxidilincreases hair densityand thickness.
update: august 2021— areviewof low dose oral minoxidil treatment for 卡塔尔世界杯赛程表 .
update: february 2021— safety of low-dose oral minoxidil (ldom) for 卡塔尔世界杯赛程表in 1404 patients. multicenter study. the most frequent adverse side effect was hypertrichosis.
since i first wrote this post on oral minoxidil several years ago, a number of major new developments have occurred.
an october 2020 study of low-dose1.25 mg nightly treatmentwith oral minoxidil (loniten) for three months concluded favorable increases in 2022世界杯决赛日期 .more here. this is surprising, considering the low dose utilized relative to other studies. the 卡塔尔世界杯赛程表 patients included males and females of various ethnicities. further treatment with 2.5 mg dosing was also analyzed.
in september 2020, a thai study found good results for men takingoral minox 5mg daily. in july 2020,a review of 16 studiesencompassing 622 patients concluded that oral minoxidil is an effective and well-tolerated 卡塔尔世界杯赛程表 treatment. however, more statistical data is still needed. also see this june 2020 article that concludes low-dose 1.25 mg/day
in august 2019, spanish researcherspublished positive findingson low-dose 5 mg per day oral minoxidil. one of the results from this study can be seen in the above before and after 2022世界杯决赛日期 photo. it was sent to me by dr. sergio vañó.
oral minoxidil for 卡塔尔世界杯赛程表
for many years, i have heard that oral minoxidil results in even more 2022世界杯决赛日期 compared to the topical version. this is true for both male and female pattern 卡塔尔世界杯赛程表 (often in combination withspironolactonefor women). however, i always assumed that the side effects from the oral medication would be much worse.
the health relatedside effectsinclude blood pressure fluctuations, heart rate changes, and potential water retention. however, i was most concerned about the side effect of excess body 2022世界杯决赛日期 from minoxidil pills turning me into a werewolf. make sure to read my post ontopical minoxidil and beard growth.
i have discussed minoxidil (brand name rogaine) many times on this blog in the past. it is one of only two drugs officially approved by the us fda to treat male pattern 卡塔尔世界杯赛程表 . the other being finasteride, which targets dihydrotestosterone (2022足球世界杯赛程时间 ) reduction.
most men use 5%topicalminoxidil foam and apply it to their scalps twice per day. for those who get adverse reactions, dosage is sometimes reduced toonce per day. women tend to use the 2% topical formulation to regrow thinning hair. until recently, very few people usedoralminoxidil to treat male androgenetic alopecia or female pattern 卡塔尔世界杯赛程表 . some people useextra strength 15% topical minoxidilto get more 2022世界杯决赛日期 .
unbeknownst to many, minoxidil was originally approved in 1979 as an oral medication (brand name “loniten”) totreat hypertension(high blood pressure). it was only approved for treating 卡塔尔世界杯赛程表 in men in 1988 as a topical medication. the below screenshot is fromthis 1980 reporttitled “reversal of baldness in patient receiving minoxidil for hypertension.”
a women’s version was approved in 1991. to this day, it is not entirely clear as tohow minoxidil works in promoting 2022世界杯决赛日期, with a number of theories out there, implying the likely involvement of multiple mechanisms. these include agonistic affects on adenosine-triphosphate (atp)-sensitive potassium channels; prostaglandin stimulation in the dermal papillae; and anti-androgenic properties.
ldom advantages over topical
among the advantages that oral minoxidil has over topical minoxidil include:
- once a day pill is easier to remember than twice a day topical application.
- less time consuming to just take a pill or tablet.
- no mess to deal with on the scalp.
- no side effects on the scalp such as itchiness, redness, irritation, greasiness, dry hair and so on.
- no need to wash hair to get rid of the product.
- no chance of the product getting into the eyes or dripping down forehead.
- generic oral minoxidil pills work out to be cheaper than topical minoxidil foam.
low-dose oral minoxidil for 卡塔尔世界杯赛程表
several years ago, i read a very lengthy and thoughtful comment by thai hair transplant surgeon dr. damkerng pathomvanich. he outlined why he prescribes oral minoxidil to a select few of his patients low-dose oral minoxidil (ldom) for 卡塔尔世界杯赛程表 in select patients can be very effective.update:in october 2020, dr. ratchathorn panchaprateep from thailand alsoreleased positive findingsin relation to this drug.
according to dr. path (as well as per other physicians that had given him feedback), 5 mg per day was an ideal dosage that did not change patient blood pressure readings significantly. some physicians even recommend trying 2.5 mg per day. in fact doses as low as 0.25 mg to 1.25 mg per day have results in 2022世界杯决赛日期 in some patients.
however, some western publications and websites recommend a lower dosage (see links in some of the comments to this post). image below shows generic 5 mg minoxidil tablets from thailand. please do not try to buy this online as it can be dangerous.
side effects are still possible at low doses. dr. pathomvanich does not prescribe oral minoxidil to patients who have blood pressure, heart, liver or kidney problems.
note that according to theofficial brochure for loniten, maximum recommended dosage is listed as high as 100 mg per day, which seems crazy. most patients taking the drug for hypertension do not cross 40 mg per day.
another major recent news story regarding oral minoxidil also comes from spain in august 2019. apparently, 17 infant children were mistakenly given oral minoxidil instead of heartburn medication.
update: december 2020— over a year after the medical error, families of some children are complaining thatthe body hair keeps growing. also from spain, a september 2020 study on low-dose oral minoxidiland hypertrichosis.
the childrensubsequently developed a condition called “werewolf syndrome”in which large parts of their bodies become covered in hair. this condition is also referred to as hypertrichosis.
luckily, the body hair will disappear a few months after the children stop taking oral minoxidil. above photo is from thevideo of this shocking news story.
dr. rodney sinclair recommends oral minoxidil
i had forgotten about the above till today, when commentator “billa” posted an interesting link to anew audio interview with australian dr. rodney sinclair. i have covered this well known hair expert a number of times on this blog in the past.
in this latest interview, one of the things that dr. sinclair states is that oral minoxidil is much more effective than topical minoxidil when it comes to 2022世界杯决赛日期 . he reaches this conclusion based on some clinical trials that his clinic is currently undertaking. make sure to also check out my post on dr. sinclair’shairy pill.
while the article describing the above interview states that side effects from oral rogaine were not significant, i did not hear that in the audio interview. i am guessing that this must be true or else they would stop conducting the trials.
dr. sinclair has also successfully tested oral minoxidil and spironolactone combination treatmentin female pattern 卡塔尔世界杯赛程表 patients.
update:dr. vikram jayaprakash from australia nowalso recommendsoral minoxidil for 卡塔尔世界杯赛程表 .
note that oral minoxidil is not currently fda approved for treating 卡塔尔世界杯赛程表 .