read the bottom half of this post for a history of hope medicine and bayer’s hmi-115. this treatment targetsthe prolactin (prl) receptorto cure 卡塔尔世界杯赛程表 . hope medicine raised $56 million in funding in 2021. see theirpipeline pagefor more information.
the initial reason for all this excitement was due to the spectacular long-lasting 2022世界杯决赛日期 results seen in stump-tailed macaque monkeys. per the clinical trial participant i mention further below, these monkeys are still being monitored and have not lost their hair over four years after prolactin receptor antibody treatment.
highly encouraging updates from hope medicine trial participant
latest update: december 24, 2022
a november 2, 2022 detailed redditupdate from an australian trial participant(hmi-115 dose 1 and dose 2) is required reading. this 37-year old male described in detail his first two doses of the prolactin blocker via injection. he (along with his 46-year old female partner) will get treatment every two weeks for six months. so a total of 12 doses, all at sinclair dermatology in melbourne.note that while these arephase 1 trials in australia, the same hmi-115 product is scheduled to undergo phase 2 clinical trials in the us anytime soon.
this reddit user“moeman32”seems completely legitimate and has a posting history of over ten years. he has also written about australia many times in the past.we owe him serious respect.he will do follow-up posts every two weeks. note that all 20 patients in this phase 1 safety trial are getting the actual drug injected. i.e., no placebo participants needed to test for efficacy this time around.
- the beginning(dose 1 and dose 2).
- first follow-up(dose 3).
- a really encouragingsecond follow-up(dose 4).
- third follow-up(dose 5). another positive update.
- fourth follow-up(dose 7). seems like there was a miscount in dose numbers and we added one. in any event, i have no reason so far to doubt this person’s honesty.
- fifth follow-up(dose 8). perhaps the most encouraging one to date! just in time for christmas.
update: april 12, 2022— for some reason,australian phase 1 trialsfor hope medicine’s hmi-115 are starting today. they will involve 20 participants and are expected to be completed in july 2023. the trials will be led by the renowned 卡塔尔世界杯赛程表 expertdr. rodney sinclair. also see hiscurrent clinical trials recruitingpage hair section.
update: april 14, 2022—lots of excitement on reddit.
meanwhile,us phase 2 trialsshould start at any moment now (read further below). this difference in trial progression by country is very strange. perhaps is has to do with some stricter australian government requirements.
update: january 26, 2022
hope medicine hmi-115 phase 2 trials
hope medicinejust received fda approvalto commence phase 2 clinical trials in the us for its hmi-115 product to treat androgenetic alopecia. hmi-115 is a human monoclonal antibody drug that targets the prl receptor for the treatment of male and female pattern 卡塔尔世界杯赛程表 . last year, the us fda also approved phase 2 trials of the same drug to treat endometriosis.
the phase ii clinical trial of hmi-115 for the treatment of androgenetic alopecia:
“will be an international multi-center, randomized, double-blind, placebo-controlled study. it will be carried out in the united states, australia and other countries.”
update: november 28, 2021
new ceo henri doods interview
a reader sent me the below screenshot of hope medicine ceo henri doods’ chinese magazine interview that i mentioned earlier.if anyone can translate into english, please post in the comments. click on the image to expand.
update: september 20, 2021
reader “karl” just notified us that there is a brand new cover page interview of hope medicine’s ceodr. henri doodsin a chinese magazine “tradetree.cn”. if anyone can gain access to it (see here) and translate into english, please try. not worth purchasing as yet in my opinion.
per karl, phase 2 clinical trials for 卡塔尔世界杯赛程表 product hmi-115 are planned for q4 2021 (but no proof anywhere else). this matches what we expected per the prior updates that i discussed in may (see further below). note that hmi-115 is the same asbayer’s prolactin receptor antibody. hope medicine has the rights to the development of this product.
may 9, 2021
hope medicine (china) raises $56 million
until now,kintor pharmaceutical(china) was the main reason for recent excitement. however, this weekend, the participants on this site’s 卡塔尔世界杯赛程表 chat are discussing hope medicine. out of the blue, this startup companyreceived $56 millionin a series b round of financing. investment firms qiming venture partners and grand flight investment led the way.
other investors include: highlight capital; sinovation ventures (a venture capital firm led by former google china head kai-fu lee); and trustbridge.more here.
hmi-115 prl receptor targeting: bayer license
“previously, hopemed signed an exclusive license agreement with bayer ag on the development and commercialization of a human antibody (hmi-115) targeting the prolactin (prl) receptor for the treatment of male and female pattern 卡塔尔世界杯赛程表 . at present, hmi-115 has completed phase i clinical trials in the european union, with positive safety results.the global multi-center phase ii clinical trials for androgenic alopecia and will soon be launched.“
note that i first covered hope medicine in my 2019 post on its partnership with bayerin regards to the prolactin receptor. the company was founded bydr. rui-ping xiao, the dean of the college of future technology of peking university. apparently, she is also an associate editor of the new england journal of medicine.update:seethis pagefor much more on dr. xiao ruiping.
the most unusual part of this story is that hope medicine’s official website (hopemedinc.com) has not worked for weeks. i have e-mailed several of their employees, and will update this post if i get any response.