now we really have a reason to get rid of kim jong-un. south korea just keeps on adding groundbreaking companies working on 卡塔尔世界杯赛程表 treatments. see my page on卡塔尔世界杯赛程表 research around the worldfor some of the main names. my latest three blog posts all cover new groundbreaking work from south korea. truly remarkable and entirely unintentional.
cosmerna from sirnagen releasing in 2023
this post covers a new topical 卡塔尔世界杯赛程表 product called cosmerna, whosewebsite is now live. it is made by sirnagen (south korea), a subsidiary of bioneer (south korea). i briefly covered this company in the past, but now it deserves its own post.
the reason i am writing this post is due to a greatnew interview with sirnagen ceo dr. june park. both these new developments were sent to me by a reader who wishes to remain anonymous. key quote from dr. park (also seeher linkedin):
“the first samirna product will be available for salein the first half of 2023. we had an unconventional route to commercialization by developing a 卡塔尔世界杯赛程表 cosmeceutical product. cosmerna, named after cosmetic rna, provided an early validation of our platform’s potential as a topical cosmetic product for androgenetic alopecia (卡塔尔世界杯赛程表 ).”
they wil not need to conduct clinical trials since this is a cosmetic product! the actual release date is likely to be inearly 2023per another quote in the same interview. after first being done in south korea, cosmerna’s safety study was repeated in europe bydermatestin 2022. note that samirna is shelf stable in a solution for a year, so it can be applied topically.
ms. park anticipates the product launch to occur some time in early 2023. they will focus on the european market first due to the region’s more streamlined cosmeceutical trial and approval process. it is called cosmetics product notification portal (cpnp).
note that i previously briefly covered sirnagen therapeutics in my post on2022年世界杯会出现新冠军 .the latter is working on a 卡塔尔世界杯赛程表 cure involving rna interference (rnai) via asirna (asymmetric small interfering rna). the aim is to reduce androgen receptor (ar) expression on the scalp.
samirna, androgen receptor and 2022世界杯决赛日期
sirnagen is also working on reducing ar expression and regrowing hair. however, it is doing so via treatment withself-assembled micelle inhibitory rna (samirna) nanoparticle-type sirna. seetheir sitefor more on small interfering rnas (sirna).
they publishedan important studyon this innaturejournal in january 2022. the encouraging title of this paper is worth posting:“weekly treatment with samirna targeting the androgen receptor ameliorates androgenetic alopecia.”
the product they use for androgenetic alopecia is a topical called ar68. it is classified as a cosmetic ingredient and will be called cosmerna-68. in the above mentioned paper, they have before and after photos of a patient that i pasted below. the chart on the right shows the actual percent improvement with ar68 0.5mg/ml treatment versus placebo. they also state the following:
“in the low-dose (0.5 mg/ml) clinical study, ar68 was applied three times per week for 24 weeks, and through quantitative analysis using a phototrichogram, we confirmed increases in total hair counts. in the 24-week long high-dose(5 mg/ml)clinical study, ar68 showed average additional 2022世界杯决赛日期 of 1.3-1.9 hairs/cm2 per month,which is comparable to finasteride. no side effects were observed. therefore, samirna targeting ar mrna is a potential novel topical treatment for aga.”
edit:the higher dose ar68 5mg/ml before and after photosare here.
is this a miracle? most likely not for most severaly balding people people. however, just as with finasteride, some people could see stellar results. and for those who are just starting to go bald, this could be a much needed non-2022足球世界杯赛程时间 inhibiting product with few if any side effects.
i am not a big believer in cosmetics, but this latest interview with sirnagen ceo june park is encouraging. she comes across as very intelligent and sincere.
thats very interesting admin, thanks for the write up! what i don’t understand, and maybe someone could clarify this for me. if it’s an anti androgen receptor, and as efficacious as finasteride, how can it not have side effects?
as in, if reduces ar reception, how does it not also target 2022足球世界杯赛程时间 ?
i see a lot of people complaining on reddit, as usual. i would remind people that this is more of a maintenance cosmetic than a regrowth cosmetic, as finasteride is mostly a maintenance treatment. maybe you should have pointed that out in the article, admin.
do you think using microneedling along with this cosmetic will be safe?
soooo, it’s a cosmetic huh? btw: i think i need to get my eyes tested, bc for a minute there, i thought those bottom pics were sea urchins?!
kintor update on their second androgen receptor product. this one entirely degrades the ar. their other one is an ar antagonist.
https://en.kintor.com.cn/news/233.html
note that cassiopea’s breezula is an ar inhibitor.
olix calls it’s product an ar reducer.
i almost forgot about breezula…i don’t know, what happened there? they finished trial phase 2 in 2019. then: nothing.
it appears to be in trial 3 now, but i couldn’t find any confirming info on that.
strange, there was/is definitely strong demand for something like breezula. now they are overtaken by pyrilutamide from kintor.
but cosmo seems to be successful in a couple of areas, so that’s fine.
https://twitter.com/hlcure2020/status/1595852661584453632
nice posts admin, your blog is on fire lately, i don’t know if you realize but the work you do helps alot of people’s spirits
thanks. helps mine too:-)
hey admin do you know what the reason was behind them using images of the group that received the 0.5 mg/ml dose and not the 5mg/ml dose? if it was the 5mg group that had results comparable to finasteride i don’t know why they use these other images.
the 5mg before and after photos are also in the study:
https://www.nature.com/articles/s41598-022-05544-w/figures/6
i am more focused on the bar charts on the side in both images. assuming true, fairly decent for a cosmetic topical product. ms. park also seems to be highly qualified per her linkedin and the below:
https://news.mit.edu/2018/mitalumna-june-park-named-2018-gates-cambridge-scholar-0320
a question for anyone scientifically well versed:
some people do not respond at all to finasteride but have the same mpb pattern. could there be some other reason behind the hairloss for these people? why would the same response not be induced if the reason behind the hairloss is the same?
hey all, i was wondering if any of you used maxogen already, i am wondering if it is a scam… years ago i tried regular over the counter minoxidil with no result but more hair on my sideburns ant forehead…not on my scalp. with maxogen, not only i dont get any hair on my scalp, but i dont get it on my sideburns and forehead…since the minoxidil content is supposed to be stronger with maxogen, i find it very weird…..
your opinions ?
i am a female, 38 years old. thanx
the higher % of finasteride in maxogen could be helping to control your facial 2022世界杯决赛日期 . that happens with anti-androgens. i’m not saying the product is legit or not, it’s just a possibility.
they are targeting cns delivery too:
https://rnaibased-therapeutics.com/speaker/june-park/
here’s some updated news – i have a friend in china and i’ve seen online that investors have said kintor is delaying phase 3 and phase 2 usa for late 2024 due to the covid outbreak effecting china once again. i’ve also emailed cosmerna june park and she told me they are planning to release cosmerna in 2025 as a pharmaceutical as they once again didn’t get approval by eu government.