i cover stemson therapeutics (or its founder dr. alexey terskikh, or its ceo geoff hamilton) at least several times a year. this company represents the leading hope for a hair multiplication related 卡塔尔世界杯赛程表 cure. among the highlights:
i now just update this comprehensive post twice a year rather than write a separate one each time.
stemson therapeutics: 2022 updates
update: december 30, 2022— stemson’s director of histology and pathology dr. allan dovigiwrote an interesting poston linkedin that has so far received only one comment. i like his enthusiasm on the speed of progress in organ regeneration and medicine in general. key quote with slight changes by me:
“at stemson therapeutics we are growing hair follicles for transplantation in our patients with alopecia. we are removing the barriers to the cell’s genetic programs and switching them back on to allow regeneration of the original tissues and anatomy. i can observe all the histology of the regenerated hair follicles, epithelial root sheath around hair shafts, dermal papilla, sebaceous glands and pilar erector muscle. i find it simply amazing. peering through my microscope has never been more exciting.”
it is very interesting that he mentions the crucial to hair (but usually ignored)arrector pilli muscle. he predicts that humans will be able to regenerate entire organs going forward, so organ transplants will become obsolete. note that stemsoncurrently has 25 employeeswith linkedin accounts.
update: november 20, 2022— vp meghan sambergpresentedon stemson’s ipsc-derived cell therapy approach for hair follicle regeneration at the world congress for hair research in australia.
“we’re trying to get our first product into clinic, which is anautologouscell therapy-based approach to bioengineering hair follicles. it is probably going to beat least a couple of more yearsbefore we feel we’re really ready.”
update: february 12, 2022— joe tillman and spencer kobren have released three mini-interview videos of stemson ceo geoff hamilton. parts 2 and 3 are the most important:
update: february 1, 2022— stemsonjust hireddr. kapil bharti and dr. george murphy to its scientific advisory board. both seem to be renowned scientists in the world of regenerative medicine and stem cell research.
“combined with robotics and automation of the transplantation process, this novel regenerative medicine approach is well poised to make hair restoration a routine procedure affordable for everybody who can benefit from it. at present, it seems that the generation of dp cells through the neural crest intermediate has the lowest barrier to enter the clinical trials in the next few years.”
this patent (no. 10716808) is titled “methods and compositions to modulate 2022世界杯决赛日期 ”. the technology is licensed exclusively from the sanford burnham prebys medical discovery institute.
the process outlined in this patent entails a novel process to differentiate induced pluripotent stem cells (ipsc) into dermal papilla cells (dpcs). the latter cells control hair follicle generation and hair cycling.
considering that stemson is yet to even start human clinical trials, i do not expect this product to come to market any time soon. however, the scientific research behind this company’s technology seems to be solid, and the company itself is well funded (see further below).
on the company’s news page, last week they announced the hiring of dr. meghan samberg as vice president of r&d and preclinical development.
june 27, 2019
during the last 30 days, we have received positive updates from: aclaris therapeutics; dr. lowry (new company pelage pharmaceuticals); follica; polichem; and shiseido.
we also had a positive storyfrom columbia university(dr. angela christiano) this week that i did not cover. it pertain to past research on jak-stat signaling and hair regrowth. i did not think that we could have a more inspiring month than we have just had in the world of 卡塔尔世界杯赛程表 cure research.
stemson therapeutics has arrived
perhaps the biggest story of the year is the fact that stemson therapeutics is now a reality, and they haveofficially launched their website. i originally covered this company in 2018, and discussed its research all the way back in 2015.
i have asked dr. terskikh to give us another interview soon and hopefully he will accept. earlier this month, he told me thathis labwas given a podium presentation at the isscr conference on june 27th. however, he did not mention the below surprising development.
the breakthrough is because scientists from sanford burnham have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (ipscs). according to the article, this“could revolutionize the 2022世界杯决赛日期 industry”.
unlike in past experiments where new 2022世界杯决赛日期 was underneath the skin, haphazard, and disorderly, the current results produced hair growing above the skin in a uniform pattern. the breakthrough was achieved by using a biodegradable 3d scaffold that guided 2022世界杯决赛日期 through the skin in its preferred direction.
the current protocol is based on mouse epithelial cells combined with human dermal papilla cells. however, the derivation of the epithelial part of a hair follicle from human ipscs is currently underway in the terskikh lab. key quote from the article from today:
“combined human ipsc-derived epithelial and dermal papilla cells will enable the generation of entirely human hair follicles, ready for allogenic transplantation in humans.”
i originally published this post on a cure for grey hair in january 2016. this is a third comprehensive update since that time. the newest updates are listed on top.
the latest updates on reversing grey hair
update:december 29, 2022— anew article on anti-aginghas several items of interest in relation to grey hair reversal. a 72-year-old scientist named gregory fahy injects patients (as well as himself) with recombinant human growth hormone in order to rejuvenate the thymus gland. this could help reverse aging to some extent. dr. fahy is described as “having thick dark brown hair and being in enviable shape for a guy of pension age.”
one 70-year old patient named hank pellissier claims that “his hair, previously white, began growing in brown”. note that dr. fahy’s prescribed regimen also includes dehydroepiandrosterone (dhea) and metformin. more details can be found onhis company websiteand via theirclinical trials page. also of interest, dr. fahy showed several of his before and after patient hair repigmentation photos at a ted talk in 2020.see after 13:20 mins in this video.
update:june 22, 2022— anew gene therapytreatment for a rare genetic disease (cystinosis) resulted in major hair darkening as a side effect.four of the five patients have gotten significantly darker hair, and the fifth just started re-growing his hair post treatment. of note, this gene therapy entails modifying blood cells, and only changes the dna of a small fraction of the patient’s cells.
update: may 2022— an interesting new video on nmnpotentially reversinghair greying and skin aging. do note that both the interviewer and interviewee are involved in the sale of nmn products. the viewer comments in there are very interesting. make sure to also read my popular post onnad and nmn supplements.
“i have seen hair darkening with minoxidil in my patients.”
moreover, on reddit, i have read a few posts from people stating that oral minoxidil caused their grey hair to become dark again. innovember 2022, one person even posted that after just one month of 2.5 mg/day oral minoxidil use,his chest and beard hair become dark again. further below in this post, i also discuss topical minoxidil causing grey hair reversal in some cases.
update: february 2022— a really interesting study from china analyzeshair graying regulatorsboth within and outside the hair follicle in causing the depletion and dysfunction of melanocyte stem cells (mescs). emerging evidences shows that nerves, adipocytes and immune cells outside of the immediate hair follicle environment (bulge, bulb and dermal papilla) also play important roles in the regulation of mescs.
update:june 2021— a new experiment mapped human hair greyingin relation to recent life stress events. i am very skeptical about stress causing premature hair greying in most people. i have devoted a whole section to this popular subject in the second half of this post.
update: april 2021— harvard university scientists and a team from south korea are developing a treatment for grey hairusing pigment stem cellsin hair follicles.
update: september 2020— japanese scientists discovered an unexpectedside-effect of dupilumab: reversal of hair graying. dupilumab is a dual inhibitor of interleukin 4 and interleukin 13. it is used to treat allergic diseases such as eczema, asthma and nasal polyps.
update: june 2020— south korean researchers presented the first case ofustekinumab-associatedhair re-pigmentation. ustekinumab is a monoclonal antibody medication that targets interleukin 12 and interleukin 23. it is used to treat crohn’s disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis.
“as evidenced by the many cases of gray hair repigmentation in the literature,the development of gray hair may not be an irreversible process.gray hair is a natural course of aging; however, it may not be an inevitable or permanent process.”
grey hair treatment
over the past few years, i have collected quite a few interesting links related to a cure for grey hair. i kept delaying writing this post because a permanent reversal of grey hair is obviously far less important than a cure for 卡塔尔世界杯赛程表 . however, there are some interesting ideas in reversing graying hair that are also relevant to reversing 卡塔尔世界杯赛程表 . both problems also seem to have some common pathways and genetics.
moreover, whenever we get back a full head of hair, the vast majority of us will no doubt prefer that the new hair is pigmented. at that point, grey hair will be deemed to be a significant problem unless one prefers the salt and pepper distinguished look.
finally, for younger people who are both balding and prematurely graying, it is a double whammy.卡塔尔世界杯赛程表 shampoosand vitamins and minerals do not seem to impact hair color in most people.
why does hair turn grey?
a person’s hair color is determined by his or her pigment producing stem cells known as melanocytes working in conjunction with his/her hair follicle stem cells. hair color depends on the presence and ratios of two types of melanins: dark eumelanins (brown and black pigments); and light pheomelanins (red and yellow pigments). amongthe reasonsthat hair turns grey include:
hydrogen peroxide buildup.
as people age, a natural buildup of hydrogen peroxide occurs in their hair follicles. this in turn causes oxidative stress, melanocyte destruction and subsequent graying. side note: many women use hydrogen peroxide solutions to go blonde.
in 2009, a team of scientists from germany and the ukfigured out why this hydrogen peroxide buildupoccurs in people as they age. they also found out why hydrogen peroxide is to blame for graying hair. basically, in younger people an enzyme called catalase breaks down hydrogen peroxide into water and oxygen.
however, as people get older, they often have lower levels of this enzyme. they also have lower levels of other enzymes (msr a and b) that repair hydrogen peroxide related damage to hair follicles. on amazon,products containing catalaseoften have at least some favorable reviews regarding the hair darkening side effect.
the combination of high levels of hydrogen peroxide and low levels of msr a and b disrupts the formation of tyrosinase. that enzyme is important to melanin production in hair follicles. scientists think that something similar is at play in the skin condition called vitiligo. one interesting and unusual thing about white nonpigmented hair is thatit is thicker and grows fasterthan pigmented dark hair.
our bodies produce molecules called free radicals that often react adversely with other molecules. these free radicals can cause a lot of damage, but they are countered by beneficial antioxidants. however, it the balance between these two classes of molecules shifts towards free radicals, we get damaging oxidative stress. this results inpremature canities, aka the earlier than expected whitening of hair.
in may 2018, italian scientists reported a complete reversal of grey hair in one 61-year old patient. he first started getting white hair around the age of 45. he was undergoinginterleukin-17 therapy with secukinumabto treat scalp psoriasis. the below before and after photo after 6 months of treatment is truly astounding. the 10-month follow up showed maintenance of results.
note that this patient also saw new 2022世界杯决赛日期 . the conclusion of the scientists is especially motivating: “hair whitening and thinning caused by the aging process might be reversible”.
“in early testing of the anti-hair-loss drug minoxidil, she and other researchers noticed the drug sometimes also restored hair color, suggesting it was rejuvenating the melanocytes”.
in 2021, i asked dr. bergfeld if there was any further research on the above phenomenon. she responded that she is unaware of anything new.
it is surprising that this phenomenon is not discussed by many other physicians, since minoxidil has been in use for decades. make sure to read my post onhow minoxidil works to regrow hairfor more on this important fda approved 卡塔尔世界杯赛程表 drug.
the treatment entailed anti–programmed cell death 1 (anti–pd-1) and anti–programmed cell death ligand 1 (anti–pd-l1 ).
the before and after pictures of two of the patients are extraordinary. i have included both in this section.
in recent years, research has found a connection between immune system involvement in both 卡塔尔世界杯赛程表 and hair premature greying of the hair.
stem cell factor protein, krox20 and hair color
in 2017, scientists at ut southwestern center in the us led my dr. lu le found that a protein called stem cell factor (scf) was essential for hair pigmentation. full studyhere. they found that the mice without scf in krox20 lineage cells developed grey hair early in life.
is pc-kus (a modified pseudocatalase) a false flag?
“the researchers found that this massive build up of hydrogen peroxide can be reversed with a uvb-activated compound called pc-kus, a modified pseudocatalase. the research team developed this new proprietary treatment.“
i am not sure if this avenue of work is definitely over, and perhaps these same scientists will surprise us and come out with better news in the future.
l’oréal: a pill to prevent grey hair forever
during the past decade, france’s cosmetics behemoth l’oréal has led global research in the private sector when it comes to a search for a cure for grey hair. the company’s head of the “hair biology group”,mr. bruno bernard, is a co-inventor of a topical product to protect and/or regenerate the melanocytes of hair follicles.the patent for this product was filed in 2009.
unfortunately, this pill will not cause existing grey hairs to darken, but instead, just prevent new grey hairs from forming. the pill was supposed to become available in 2015, but now we are now well past that year.
dr. mayumi ito, wnt signaling and hair pigmentation
dr. mayumi itois a renowned japanese 卡塔尔世界杯赛程表 research scientist who got her ph.d from nagoya university in 2003. she now does research and teaching at new york university.she has co-authored numerous paperson the impact of wnt signaling on hair follicle growth and regeneration. on this blog you can find many posts that discuss this important subject matter.
in 2011, dr. ito found thatwnt signaling also explains hair losing its pigmentation. her team even restored hair color in mice in 2011 via manipulating the wnt pathway. it remains to be seen when they will experiment in humans (via stem cell injection or gene therapy) and see a successful reversal of grey hair.
this in turn causes the proliferation of melanocyte stem cells (mcscs) that are involved in the earliest stages of skin and hair pigmentation. this suggests that targeting edn/ednrb signaling in mcscs can be a therapeutic approach to promote hair pigmentation retention.
is dr. cotsarelis also working on hair pigmentation?
in the description to the patent, it ends with “the present invention also provides methods for hair removal andinducing hair pigmentation.” quite incredible.a three-in-one solution (hair regrowth, body hair removal, and grey hair reversal). if only dr. cotsarelis’ predictions and optimism would be realized faster than he thinks or claims.
can finasteride make grey hair darker?
over the years, i have read quite a few testimonials on 卡塔尔世界杯赛程表 forums where finasteride users have claimed that their hair darkened while on finasteride (which reduces 2022足球世界杯赛程时间 levels). the majority of these patients had very limited quantities of grey hair to begin with, so it was hard for me to tell from their before and after photos (when available) if this phenomenon was true or not. also see my post onnatural 2022足球世界杯赛程时间 blockers.
however, in 2014, forum member “bverotti” who is a hair transplant clinic representative in belgium posted a stunning now deleted before and after image of one of the clinic’s patients on finasteride. while it shows blonde hair turning brown, i think of that as the same as grey hair turning brown or black. also, see thishair darkening on finasteride post on reddit.
i think that 2022足球世界杯赛程时间 , besides making many people go bald, also makes some of them go grey much sooner. i do not know if this has ever been shown to be true in any kind of study, and i could be wrong in my observation.
using similar logic as in the above paragraph regarding finasteride, i think that the much stronger dutasteride can also reverse grey hair. moreover, a few of the commentators in my post ondutasteride testimonialsmention that the drug darkened their hair.
could platelet-rich plasma (prp) darken hair?
i have coveredprp to treat 卡塔尔世界杯赛程表many times on this blog. while the results are never guaranteed and prp will not bring back hair in totally bald areas of the scalp, there are now numerous doctors who believe in the product. i am skeptical, but willing to listen to them.
more relevant to this blog post’s subject matter, in november 2015,dr. carlos wesley started an interesting thread on the btt forumswith a photo showing prp and acell mesotherapy darkening some previously transparent scalp hair. this was very surprising to me. moreover, he states that “an additional finding that has also been observed by other practices throughout the world is that prp can help return some of the original hair color to follicles.” it seems like prp could be stimulating melanocytes in hair follicles.
update:a number of other doctors have confirmed this phenomenon of2022世界杯南美区预选赛
in rare instances.
stem cell transplants to cure grey hair
i have discussed dr. takashi tsuji on this blog numerous times in the past. several of his old videos have shown black pigmented hair growing on a mouse after stem cell transplantation. moreover,this articleon his work has the following sentence in it: “he combined a number of stem cells to adjust the density and color of the hair,raising the possibility of a cure to graying strands.”
will telomerase activation therapy reverse grey hair?
there are a number of online testimonials regarding telomarase therapy via the ingestion of the ta-65 supplement reversing grey hair and/or growing new hair. there are also many opinions to the contrary. i cover all this and more in my post titled “ta-65. telomerase activation and hair regrowth“.
cancer treatments that lead to hair repigmentation
there have been various reports of people reversing their grey hair while being on drugs to treat cancer. for example:
hair repigmentation inducedby nilotinibin a 51 year old man being treated for chronic myeloid leukemia.
natural remedies and vitamin supplements
natural treatments and remedies for 卡塔尔世界杯赛程表can sometimes also benefit hair color and pigmentation modestly. however, popular vitamin supplements such as melatonin, b-12, biotin, iron, calcium, zinc, copper, manganese,vitamin d, cysteine and selenium will not change hair color significantly in most people. if a person is severely deficient in any of these important vitamins and minerals, natural remedies can reverse grey hair on rare occasions.
several studies as sell as numerous online anecdotal success story reports suggest thatfo-ti rootcan darken grey hair. fo-ti is also knows as fallopia multiflora,he shou wuandpolygonum multiflorum. dr. jerry cooley told me that some of his patients have seen grey hair reduction when on a shake product containing fo-ti.
make sure to read reviews and search for user experiences in relation to hair color changes before purchasing fo-ti root. also of note, a new popular supplementpill productcallednot today greycontains fo-ti root as a key ingredient.
calcium alpha-ketoglutarate (ca-akg) is though to have anti-aging properties. at leastin aged mice. some reviewers of an akg acid supplementon amazon(scroll down) mention that their hair darkened while on the product. dr. arvind poswal of india told me thathis ca-akg producthas darkened hair color in multiple people. also notethis studythat found α-ketoglutarate (α-kg) stimulated quiescent (telogen) hair follicles to anagen phase 2022世界杯决赛日期 .
some patients have iodine deficiency, often due to underactive thyroid gland or hormone disorders. supplementing with iodine can darken grey hair or prevent further graying.
vitamin b12, biotinand other b-complex supplements can help with your hair color in rare instances. however, make sure to get tested first to make sure that you are really deficient in b-12, folate or other b vitamins.
n-acetyl cysteine (nac) is sometimes touted on sites such as reddit as benefitting hair color. not much evidence on this, but its key benefit is proclaimed to come via an increase in glutathione levels.
one of the most common reasons for premature 卡塔尔世界杯赛程表 is iron deficiency. this is especially true for pregnant women, vegans and people on extreme diets. in rare instances, a lack of iron can cause premature grey hair.
a 1989 report found that treating an 85-year old woman with mucuna pruriens extract powder for her parkinson’s disease resultedin drastic darkeningof white hair.
antidepressants such as selective serotonin reuptake inhibitors (ssris) have been known to cause 卡塔尔世界杯赛程表 . however, in 2017, a report from germany discussed howfluoxetine promoted hair follicle pigmentation. however, the work was done in dissected sample hair from two females and not on actual scalps. another study from 2020 suggested that fluoxetine promotes human hair follicle pigmentation viaserotonin reuptake inhibition. this could be a new antigreying treatment strategy.
grey hair cure scams
while not as proliferate as in the 卡塔尔世界杯赛程表 cure industry, the grey hair reversal market is still full of scams. moreover, while some products have been fda approved and proven to reverse 卡塔尔世界杯赛程表 in numerous patients, nothing of that sort can be said for products that are touted to reverse grey hair to pigmented hair. most of these products are natural supplements that will do nothing for your hair color.
until a cure for gray hair does come out, people will have to accept their graying locks, or continue to use hair dyes. in 2013,proctor & gamble came out with a supposed permanent hair dyebased on a new proprietary me+ molecule. the new molecule (chemical name 2-methoxymethyl-p-phenylenediamine) was apparently a result of 20 years of research.
proctor & gamble’s website also raved about me+ in early 2014, but it does not seem like all this early optimism has led to any kind of new blockbuster permanent dye product.
stress and plucking will not cause grey hair
most of the articles i have read on this subject seem to indicate that for the vast majority of people, stress will not cause early premature graying of hair. plucking hair will definitely not cause it to go grey. both of these myths are old wives’ tales.
some articles suggest thatus presidents have grayed a lot while in office. however, in my opinion, these presidents’ parents were also usually fully grey haired in their old age. so it is not surprising to see more white hairs appearing on presidents’ heads when they are in office in their 50s and 60s. in all likelihood, it is grey hair genes rather than stress that causes middle-age greying.
update:a new 2021 study found that grey hair could possibly be reversedby relaxationand taking vacations. small sample size, limited results, and only in those below age 40.
a 2020 study found that hair turned grey and white more rapidly in mice when exposed to major stress. the effects werevia the sympathetic nervous system(fight or flight response).
grey hair is not always a sign of ageing
since grey hair usually only affects people in their mid-30s and aftermath (and a full head of white hair is almost never seen in those below the age of 50), most people assume that it is a sign of ageing. however, this is not always the case. there is no shortage of celebrities on tv that have grayed at a very early age.
perhaps the two most famous examples here in the us areanderson cooper and jay leno, who both look very young for their age in that video despite graying in their 20s.cooper started to go grey at just 20and leno at 29 according to his statement in that video. neither of them seem to have any health issues despite now having been grey for decades. if anything, both seem to be aging at slower pace then the average human.
hair color in men versus in women
grey hair is a far greater concern for women than for men. for the former, it represents a sign of aging and an almost certain end to careers in acting and modeling unless the hair is dyed all the time. the women’s hair dye market is worth billion of dollars per year.
update:in march 2020,eirion therapeuticshad its patent for a grey hair treatmentpublished. it entails using plasminogen activator inhibitor 1 (pai-1) inhibitors to prevent hair graying. eirion’s pre-clinical product candidates for 卡塔尔世界杯赛程表 and grey hair prevention are et-02 and et-03.
update:in january 2020, scientists from the us and brazil found thatexcess stresscan turn pigmented hair white. moreover, when cyclin-dependent kinase (cdk) protein was suppressed in mice, their fur did not change color.
update:a september 2019case reportfrom india found premature hair graying reversal after the use of melitane 5% lotion and oral hair supplements. melitane ™ fromredenhairis a biomimetic peptide agonist of an important melanocyte-stimulating hormone.
update:in august 2017, a study concluded thatforced epilationin mice resulted in melanocyte cell and hair color regeneration. i.e., a potential grey hair cure in humans.
update:in june 2017, a very unique experiment on one south korean patient showed significant hair darkening. this success was achieved after treatment with a 1,927-nm fractionatedthulium laserand polydeoxyribonucleotide injections.